Enabling technology for therapeutics targeting membrane proteins

We express, stabilize, select and validate membrane protein as targets
CONTACT

G.CLIPS biotech created the first enabling technology to unravel the potential of drug and antibody candidates on pathology-like format membrane proteins to be used in screening efforts, characterization, structural studies, mechanism of action, pharmacological profiling and target validation.

We offer a unique technology to express, stabilize, select and validate membrane proteins as targets based on proprietary G.Screen® Platform.

G.Mixes®
G.Select® Assay
G.Lipidomics®
G.Validation® Assay

We provide tailor-made services to pharma, biotech and animal health companies targeting membrane proteins (GPCRs, Receptors, Transmembrane Proteins) that would like to ascertain the necessary environment and conformation stabilization for their targets at all steps of development.

– Delivery of membrane proteins purified and stabilized in the desired conformation and specific environment for screening

– Delivery of membrane proteins purified and stabilized in the desired conformation and specific environment for immunization

– Mechanism of action and functional testing of drugs and antibody candidates on membrane protein stabilized in specific conformation(s) and environment(s)

– Target validation and profiling of drugs and antibody hits, leads and clinical candidates

PROBLEMS WE SOLVE

>> SOLUTIONS WE BRING

Antibody & Antigen Discovery

Antibody discovery and characterization
Antigens for immunization
Target Validation

>> NEW AND LEAD-LIKE ANTIBODY

 Conformational and Environment sensitive antibody
 Antibodies with improved therapeutic window
 Improved binders’ ratio and vaccination success.

Drug Discovery

Pathology-oriented drug in vitro screen
Target validation
Structure-based drug discovery
In vitro candidates profiling

>> LEAD-LIKE NEW CHEMICAL ENTITY

 New families of biased and allosteric candidates
 Improved indication selectivity
Improved new chemical entity efficacy

Non Clinical development​

 Toxicity due to selectivity
 Pharmacology in vitro
Mechanism of action

>> De-risking & Profiling of clinical candidate

Selectivity on pathology vs non-pathology like environment
Pharmacological profiling of clinical candidate
Target characterization / validation 

Ecosystem and partners

Stanford University
Université Libre de Bruxelles
Université de Lausanne
Université de Lausanne
Stanford University
Université Libre de Bruxelles
Université de Lausanne
Université de Lausanne
Stanford University
Université Libre de Bruxelles
Université de Lausanne
Université de Lausanne
Université de Lausanne

Any project ?
Any need ?